Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide: An Open-Label Clinical Trial Among Hypertensive Subjects

Introduction: The conversion of dietary inorganic nitrate (NO3-) to nitric oxide (NO) is a non-canonical pathway that plays an important role in NO biology, especially under pathological conditions. Inorganic NO3- supplementation proven method for controlling mild hypertension. Recent reports have suggested another gaseous transmitter, hydrogen sulfide (H2S), influences biosynthesis and metabolism. Here, data are presented from open-label clinical trial examining the effect encapsulated formulation (Vascanox® HP) combines sources S-allylcysteine (SAC), source H2S garlic, on bioavailability blood pressure subjects experiencing elevated or Methods: An was conducted among patients with Participants took Vascanox® four weeks. Blood measured at baseline, two weeks, Salivary nitrite (NO2-), surrogate bioavailability, were assessed prior two, six, 24 hours after dosing first day study subsequent visits using saliva test strips. Changes outcomes over time evaluated via analysis variance (ANOVA) paired t-tests. Results: Twelve participants completed trial. HP decreased systolic by ~11 mmHg (p < 0.001) weeks persisted beyond daily supplementation. It also diastolic hypertensive but not normotensive ones. magnitude decrease 11 0.01) study. Measurements salivary concentrations NO2- revealed high peak levels (743 uM) post-administration slow decay (348 hours. concentrations, biomarker remained above baseline duration Conclusions: shown be safe, effective, quick-acting, long-lasting supplement